We assumed age-dependent penetrance of mutations in a so far unknown gene causing late-onset CMT2.
Late-onset axonal Charcot-Marie-Tooth neuropathy (CMT2) is an autosomal-dominantly inherited condition that manifests in the second half of life and is genetically largely unexplained.
Common etiologies comprise diabetes mellitus, paraproteinaemia, and inflammatory disorders, but often the underlying causes remain elusive. Electronic address: polyneuropathies are a frequent cause of progressive disability in the elderly.